| MATCH | TIP | TIME | DATE |
|---|---|---|---|
| Alajuelense vs Guanacasteca | 1 | 02:00 | 2022-01-23 |
| Mes Kerman vs Astara | 1 | 13:30 | 2022-01-23 |
| Sancaktepe vs Karaman Bld. | Canceled | 13:00 | 2022-01-23 |
| Hacettepe vs Iskenderun | 2 | 13:00 | 2022-01-23 |
| Siirt Ozel vs Igdir FK | 2 | 13:00 | 2022-01-23 |
| Ofspor vs Modafenspor | 1 | 13:00 | 2022-01-23 |
| Villarreal B vs Sanluqueno | 1 | 14:00 | 2022-01-23 |
| Kalamata vs Rodos | Canceled | 15:45 | 2022-01-23 |
| Panathinaikos B vs Levadiakos | 2 | 15:45 | 2022-01-23 |
| Chiangmai FC vs Khonkaen FC | 1 | 15:00 | 2022-01-23 |
